Discovery of Flavonoids from Scutellaria baicalensis with Inhibitory Activity Against PCSK 9 Expression: Isolation, Synthesis and Their Biological Evaluation

Nine flavonoids were isolated and identified from a chloroform-soluble fraction of the roots of Scutellaria baicalensis through a bioactivity-guided fractionation using a proprotein convertase subtilisin/kexin type 9 (PCSK9) monitoring assay in HepG2 cells. All structures were established by interpr...

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Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Nhoek, Piseth, Chae, Hee-Sung, Masagalli, Jagadeesh Nagarajappa, Mailar, Karabasappa, Pel, Pisey, Kim, Young-Mi, Choi, Won Jun, Chin, Young-Won
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100156/
https://ncbi.nlm.nih.gov/pubmed/29495284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020504
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