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Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N
A new directed evolution approach is presented to enhance the activity of an enzyme and to manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) simultaneously on residues lining the entrance tunnel and the binding pocket. This combined mutagenesis strategy was applied succ...
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| Publicado en: | Chem Sci |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099926/ https://ncbi.nlm.nih.gov/pubmed/30155214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05381e |
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