Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

The local environment is crucial for shaping the identities of tissue-resident macrophages (Mϕs). When hemorrhage occurs in damaged tissues, hemoglobin induces differentiation of anti-inflammatory Mϕs with reparative function. Mucosal bleeding is one of the pathological features of inflammatory bowe...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kayama, Hisako, Kohyama, Masako, Okuzaki, Daisuke, Motooka, Daisuke, Barman, Soumik, Okumura, Ryu, Muneta, Masato, Hoshino, Katsuaki, Sasaki, Izumi, Ise, Wataru, Matsuno, Hiroshi, Nishimura, Junichi, Kurosaki, Tomohiro, Nakamura, Shota, Arase, Hisashi, Kaisho, Tsuneyasu, Takeda, Kiyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099887/
https://ncbi.nlm.nih.gov/pubmed/30061415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808426115
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