Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

OBJECTIVE: To develop an objective, readily measurable pharmacodynamic biomarker of glucocorticoid (GC) activity. METHODS: Genes modulated by prednisolone were identified from in vitro studies using peripheral blood mononuclear cells from normal healthy volunteers. Using the criteria of a >2‐fold...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Hu, Yanhua, Carman, Julie A., Holloway, Deborah, Kansal, Selena, Fan, Li, Goldstine, Christine, Lee, Deborah, Somerville, John E., Latek, Robert, Townsend, Robert, Johnsen, Alyssa, Connolly, Sean, Bandyopadhyay, Somnath, Shadick, Nancy, Weinblatt, Michael E., Furie, Richard, Nadler, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Autoimmune Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099349/
https://ncbi.nlm.nih.gov/pubmed/29534336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40476
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