Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury

Acetaminophen (paracetamol‐APAP) is the most common cause of drug‐induced liver injury in the Western world. Reactive metabolite production by cytochrome P450 enzymes (CYP‐metabolites) causes hepatotoxicity. We explored the toxicokinetics of human circulating APAP metabolites following overdose. Pla...

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Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Vliegenthart, ADB, Kimmitt, RA, Seymour, JH, Homer, NZ, Clarke, JI, Eddleston, M, Gray, A, Wood, DM, Dargan, PI, Cooper, JG, Antoine, DJ, Webb, DJ, Lewis, SC, Bateman, DN, Dear, JW
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099202/
https://ncbi.nlm.nih.gov/pubmed/27770431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.541
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