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Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity
Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN). FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S...
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| Publicado no: | Biochimie |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Editions Scientifiques Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6098246/ https://ncbi.nlm.nih.gov/pubmed/30031876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2018.07.012 |
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