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Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy
Food allergy poses a significant clinical and public health burden affecting 2–10% of infants. Using integrated DNA methylation and transcriptomic profiling, we found that polyclonal activation of naive CD4+ T cells through the T cell receptor results in poorer lymphoproliferative responses in child...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6098117/ https://ncbi.nlm.nih.gov/pubmed/30120223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05608-4 |
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