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(Pro)Renin receptor mediates obesity-induced antinatriuresis and elevated blood pressure via upregulation of the renal epithelial sodium channel

Recent studies have demonstrated that the renal (pro)renin receptor (PRR) regulates expression of the alpha subunit of the epithelial sodium channel (α-ENaC). In this study we hypothesized that the renal PRR mediates high fat diet (HFD)-induced sodium retention and elevated systolic blood pressure (...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Quadri, Syed S., Culver, Silas, Ramkumar, Nrupama, Kohan, Donald E., Siragy, Helmy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097690/
https://ncbi.nlm.nih.gov/pubmed/30118514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202419
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