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Upregulating the mevalonate pathway and repressing sterol synthesis in Saccharomyces cerevisiae enhances the production of triterpenes

Pentacyclic triterpenes are diverse plant secondary metabolites derived from the mevalonate (MVA) pathway. Many of these molecules are potentially valuable, particularly as pharmaceuticals, and research has focused on their production in simpler and more amenable heterologous systems such as the yea...

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Detalhes bibliográficos
Publicado no:Appl Microbiol Biotechnol
Main Authors: Bröker, Jan Niklas, Müller, Boje, van Deenen, Nicole, Prüfer, Dirk, Schulze Gronover, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096838/
https://ncbi.nlm.nih.gov/pubmed/29948122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-018-9154-7
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