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Upregulating the mevalonate pathway and repressing sterol synthesis in Saccharomyces cerevisiae enhances the production of triterpenes

Pentacyclic triterpenes are diverse plant secondary metabolites derived from the mevalonate (MVA) pathway. Many of these molecules are potentially valuable, particularly as pharmaceuticals, and research has focused on their production in simpler and more amenable heterologous systems such as the yea...

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Bibliografske podrobnosti
izdano v:Appl Microbiol Biotechnol
Main Authors: Bröker, Jan Niklas, Müller, Boje, van Deenen, Nicole, Prüfer, Dirk, Schulze Gronover, Christian
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096838/
https://ncbi.nlm.nih.gov/pubmed/29948122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-018-9154-7
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