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Efficient Genome Engineering of a Virulent Klebsiella Bacteriophage Using CRISPR-Cas9

Klebsiella pneumoniae is one of the most common nosocomial opportunistic pathogens and usually exhibits multiple-drug resistance. Phage therapy, a potential therapeutic to replace or supplement antibiotics, has attracted much attention. However, very few Klebsiella phages have been well characterize...

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Pubblicato in:J Virol
Autori principali: Shen, Juntao, Zhou, Jinjie, Chen, Guo-Qiang, Xiu, Zhi-Long
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096830/
https://ncbi.nlm.nih.gov/pubmed/29899105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00534-18
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