The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has evolved effective mechanisms to counteract the type I interferon (IFN) response. Upon recognition of the virus, cells secrete IFNs, which signal through transmembrane receptors (IFNAR) to phosphorylate STAT proteins (pSTAT). pSTAT dim...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Göertz, Giel P., McNally, Kristin L., Robertson, Shelly J., Best, Sonja M., Pijlman, Gorben P., Fros, Jelke J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2018
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096799/
https://ncbi.nlm.nih.gov/pubmed/29925658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01008-18
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