Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus

BACKGROUND: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. Patients are susceptible to severe enterovirus infections. The underlying mechanism remains unknown. BTK is involved in toll-like receptors pathway, which initiates antivira...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Luk, Anderson Dik Wai, Ni, Ke, Wu, Yuet, Lam, Kwok-Tai, Chan, Koon-Wing, Lee, Pamela P., Tu, Wenwei, Mao, Huawei, Lau, Yu Lung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095995/
https://ncbi.nlm.nih.gov/pubmed/30147693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01826
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