Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer in vitro and in vivo

PURPOSE: Mitochondrial glycerophosphate dehydrogenase (mGPDH) is the key enzyme connecting oxidative phosphorylation (OXPHOS) and glycolysis as well as a target of the antidiabetic drug metformin (MF) in the liver. There are no data on the expression and role of mGPDH as a metformin target in cancer...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Thakur, Shilpa, Daley, Brianna, Gaskins, Kelli, Vasko, Vasyl V, Boufraqech, Myriem, Patel, Dhaval, Sourbier, Carole, Reece, Jeff, Cheng, Sheue-Yann, Kebebew, Electron, Agarwal, Sunita, Klubo-Gwiezdzinska, Joanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095745/
https://ncbi.nlm.nih.gov/pubmed/29691295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3167
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