Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

Tumor cells evade the immune surveillance by up-regulating surface expression of PD-L1, which interacts with PD-1 on T cells to elicit the immune checkpoint response(1,2). Anti-PD-1 antibodies have shown remarkable promise in treating tumors, including metastatic melanoma(2–4). However, patient resp...

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Gepubliceerd in:Nature
Hoofdauteurs: Chen, Gang, Huang, Alexander C., Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F., Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H., Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C., Gangadhar, Tara C., Schuchter, Lynn M., Herlyn, Meenhard, Wherry, E. John, Xu, Xiaowei, Guo, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095740/
https://ncbi.nlm.nih.gov/pubmed/30089911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0392-8
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