Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to investigate the impact of type I IFNs on hematopoie...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Smith, Julianne N. P., Zhang, Yubin, Li, Jing Jing, McCabe, Amanda, Jo, Hui Jin, Maloney, Jackson, MacNamara, Katherine C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095620/
https://ncbi.nlm.nih.gov/pubmed/30080899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007234
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