Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

It is uncertain which β4-galactosyltransferase (β4GalT; gene name, B4galt), β4GalT-5 and/or β4GalT-6, is responsible for the production of lactosylceramide (LacCer) synthase, which functions in the initial step of ganglioside biosynthesis. Here, we generated conditional B4galt5 knockout (B4galt5 cKO...

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Publicado en:PLoS Genet
Autores principales: Yoshihara, Toru, Satake, Hiroyuki, Nishie, Toshikazu, Okino, Nozomu, Hatta, Toshihisa, Otani, Hiroki, Naruse, Chie, Suzuki, Hiroshi, Sugihara, Kazushi, Kamimura, Eikichi, Tokuda, Noriyo, Furukawa, Keiko, Fururkawa, Koichi, Ito, Makoto, Asano, Masahide
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095488/
https://ncbi.nlm.nih.gov/pubmed/30114188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007545
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