The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

BACKGROUND: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experim...

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Detaylı Bibliyografya
Yayımlandı:BMC Neurosci
Asıl Yazarlar: Asadi, Saeedeh, Roohbakhsh, Ali, Shamsizadeh, Ali, Fereidoni, Masoud, Kordijaz, Elham, Moghimi, Ali
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090721/
https://ncbi.nlm.nih.gov/pubmed/30103703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-018-0445-9
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