Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance

Genome-scale CRISPR-Cas9 Knockout Screening was applied to investigate novel targets in imatinib-resistant gastrointestinal stromal tumor (GIST). 20 genes and 2 miRNAs have been selected by total reads of sgRNA and sgRNA diversity, which has been further validated in imatinib-resistant GIST cells by...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Cao, Jie, Wei, Jianchang, Yang, Ping, Zhang, Tong, Chen, Zhuanpeng, He, Feng, Wei, Fang, Chen, Huacui, Hu, He, Zhong, Junbin, Yang, Zhi, Cai, Wensong, Li, Wanglin, Wang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Letter to the Editor
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090611/
https://ncbi.nlm.nih.gov/pubmed/30103756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0865-2
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