Association of Variability and Pharmacogenomics With Bioequivalence of Gefitinib in Healthy Male Subjects

Objective: The aim of the study was to explore the association of pharmacokinetic variability and pharmacogenomics with the bioequivalence of orally administered gefitinib (Iressa®, AstraZeneca) provided by three sponsors in healthy subjects. Methods: The study designs were randomized, open-label, a...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhang, Hong, Li, Qingmei, Zhu, Xiaoxue, Wu, Min, Li, Cuiyun, Li, Xiaojiao, Liu, Chengjiao, Shen, Zhenwei, Ding, Yanhua, Hua, Shucheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090208/
https://ncbi.nlm.nih.gov/pubmed/30131694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00849
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