Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group

Introduction: The multi-copied genes coding for the human 18, 5.8, and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA. Human genome contains unmethylated, slightly methylated, and hypermethylated copies of rDNA. The major research question: What...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Malinovskaya, Elena M., Ershova, Elizaveta S., Golimbet, Vera E., Porokhovnik, Lev N., Lyapunova, Nataliya A., Kutsev, Serguey I., Veiko, Natalia N., Kostyuk, Svetlana V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090032/
https://ncbi.nlm.nih.gov/pubmed/30131826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00306
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