Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents

Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus (EBOV) activities. Structure—activity relationship analysis indicated: (i) 12N-dichlorobenzyl motif was beneficial for...

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Bibliografiske detaljer
Udgivet i:Acta Pharm Sin B
Main Authors: Zhang, Xin, Liu, Qiang, Li, Qianqian, Li, Yinghong, Liu, Zhandong, Deng, Hongbin, Tang, Sheng, Wang, Yanxiang, Wang, Youchun, Song, Danqing
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089848/
https://ncbi.nlm.nih.gov/pubmed/30109186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.01.006
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