Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady‐state disposition of lamotrigine in adults with epilepsy

AIMS: To investigate the impact of glucuronidation enzyme (UGT1A4*3 142T>G, UGT1A4*2 70C>A, UGT2B7 –161C>T) and transporter (MDR1/ABCB1 1236C>T, ABCG2 421C>A) polymorphisms on steady‐state disposition of lamotrigine and on the lamotrigine–valproate interaction. METHODS: Adults with ep...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Klarica Domjanović, Iva, Lovrić, Mila, Trkulja, Vladimir, Petelin‐Gadže, Željka, Ganoci, Lana, Čajić, Ivana, Božina, Nada
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089815/
https://ncbi.nlm.nih.gov/pubmed/29791014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13646
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