IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3- and p38 MAPK-mediated signals

Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons...

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Detalhes bibliográficos
Publicado no:Int J Mol Med
Main Authors: Ohta, Maiko, Chosa, Naoyuki, Kyakumoto, Seiko, Yokota, Seiji, Okubo, Naoto, Nemoto, Akira, Kamo, Masaharu, Joh, Shigeharu, Satoh, Kenichi, Ishisaki, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089780/
https://ncbi.nlm.nih.gov/pubmed/29901090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm_2018.3714
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