Conformational changes in amyloid-beta (12–28) alloforms studied using action-FRET, IMS and molecular dynamics simulations

Small oligomers of the amyloid beta protein (Aβ) have been implicated as the neurotoxic agent leading to Alzheimer's disease, and in particular mutations in the hydrophobic core region comprising amino acids L17 to A21 have a large influence on the propensity for aggregate formation. It has bee...

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Udgivet i:Chem Sci
Main Authors: Daly, Steven, Kulesza, Alexander, Poussigue, Frederic, Simon, Anne-Laure, Choi, Chang Min, Knight, Geoffrey, Chirot, Fabien, MacAleese, Luke, Antoine, Rodolphe, Dugourd, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2015
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088554/
https://ncbi.nlm.nih.gov/pubmed/30155007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01463h
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