The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis

The common gain-of-function MUC5B promoter variant (rs35705950) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). While the role of complement in IPF is controversial, both MUC5B and the complement system play a role in lung host defense. The aim of this study...

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發表在:Am J Physiol Lung Cell Mol Physiol
Main Authors: Okamoto, Tsukasa, Mathai, Susan K., Hennessy, Corinne E., Hancock, Laura A., Walts, Avram D., Stefanski, Adrianne L., Brown, Kevin K., Lynch, David A., Cosgrove, Gregory P., Groshong, Steve D., Cool, Carlyne D., Schwarz, Marvin I., Banda, Nirmal K., Thurman, Joshua M., Yang, Ivana V., Holers, V. Michael, Schwartz, David A.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087895/
https://ncbi.nlm.nih.gov/pubmed/29565179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00395.2017
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