Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages

Chemotherapy-induced immunosuppression poses an additional challenge to its limited efficacy in pancreatic cancer (PC). Here we investigated the effect of gemcitabine on macrophages, which are the first line of immune-defense mechanisms. We observed an increased presence of macrophages in orthotopic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Deshmukh, Sachin Kumar, Tyagi, Nikhil, Khan, Mohammad Aslam, Srivastava, Sanjeev Kumar, Al-Ghadhban, Ahmed, Dugger, Kari, Carter, James Elliot, Singh, Seema, Singh, Ajay Pratap
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086900/
https://ncbi.nlm.nih.gov/pubmed/30097594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30437-2
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