Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

The nucleus represents a cellular compartment where the discrimination of self from non-self nucleic acids is vital. While emerging evidence establishes a nuclear non-self DNA sensing paradigm, the nuclear sensing of non-self RNA, such as that from nuclear-replicating RNA viruses, remains unexplored...

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Udgivet i:Nat Commun
Main Authors: Liu, GuanQun, Lu, Yao, Thulasi Raman, Sathya N., Xu, Fang, Wu, Qi, Li, Zhubing, Brownlie, Robert, Liu, Qiang, Zhou, Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086882/
https://ncbi.nlm.nih.gov/pubmed/30097581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05745-w
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