Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocu...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Chen, Huihui, Cho, Kin-Sang, Vu, T. H. Khanh, Shen, Ching-Hung, Kaur, Mandeep, Chen, Guochun, Mathew, Rose, McHam, M. Lisa, Fazelat, Ahad, Lashkari, Kameran, Au, Ngan Pan Bennett, Tse, Joyce Ka Yu, Li, Yingqian, Yu, Honghua, Yang, Lanbo, Stein-Streilein, Joan, Ma, Chi Him Eddie, Woolf, Clifford J., Whary, Mark T., Jager, Martine J., Fox, James G., Chen, Jianzhu, Chen, Dong F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086830/
https://ncbi.nlm.nih.gov/pubmed/30097565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05681-9
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