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Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
Ideally, somatic gene therapy should result in lifetime reversal of genetic deficiencies. However, to date, phenotypic correction of monogenic hyperlipidemia in mouse models by in vivo gene therapy has been short-lived and associated with substantial toxicity. We have developed a helper-dependent ad...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The National Academy of Sciences
2001
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60862/ https://ncbi.nlm.nih.gov/pubmed/11687662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241506298 |
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