ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD). Recent studies using animal models show that autism-related behavior can be rescued by either manipulating actin regulators or by r...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Hlushchenko, Iryna, Khanal, Pushpa, Abouelezz, Amr, Paavilainen, Ville O., Hotulainen, Pirta
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085419/
https://ncbi.nlm.nih.gov/pubmed/30123108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00217
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