MPO promoter polymorphism rs2333227 enhances malignant phenotypes of colorectal cancer by altering the binding affinity of AP-2α

Myeloperoxidase (MPO) promoter single nucleotide polymorphisms (SNPs) rs2243828 (−764T>C) and rs2333227 (G-463A) program malignant phenotypes by regulating MPO transcriptional activity. In this study, we enrolled a total of 1,175 controls and 1,078 colorectal cancer (CRC) patients with comprehens...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Meng, Qingtao, Wu, Shenshen, Wang, Yajie, Xu, Jin, Sun, Hao, Lu, Runze, Gao, Na, Yang, Hongbao, Li, Xiaobo, Tang, Boping, Aschner, Michael, Chen, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084780/
https://ncbi.nlm.nih.gov/pubmed/29540402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2538
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