Inactivation of CDK12 delineates a distinct immunogenic class of advanced prostate cancer

Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK...

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Publicado no:Cell
Main Authors: Yi-Mi, Wu, Cieslik, Marcin, Lonigro, Robert J., Pankaj, Vats, Reimers, Melissa A., Xuhong, Cao, Yu, Ning, Lisha, Wang, Kunju, Lakshmi P., de Sarkar, Navonil, Heath, Elisabeth I., Jonathan, Chou, Feng, Felix Y., Nelson, Peter S., de Bono, Johann S., Weiping, Zou, Bruce, Montgomery, Alva, Ajjai, Robinson, Dan R., Chinnaiyan, Arul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084431/
https://ncbi.nlm.nih.gov/pubmed/29906450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.034
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