New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors

A series of new (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates 4–6(a–i) were synthesized and evaluated for their antiproliferative activity on selected human cancer cell lines such as prostate (DU-145), lung (A549), cerv...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Mullagiri, Kishore, Nayak, V. Lakshma, Sunkari, Satish, Mani, Geeta Sai, Guggilapu, Sravanthi Devi, Nagaraju, Burri, Alarifi, Abdullah, Kamal, Ahmed
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083797/
https://ncbi.nlm.nih.gov/pubmed/30108921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00450h
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