A Bovine Adenoviral Vector-Based H5N1 Influenza -Vaccine Provides Enhanced Immunogenicity and Protection at a Significantly Low Dose

Several human and nonhuman adenovirus (AdV) vectors including bovine AdV type 3 (BAdV-3) were developed as gene delivery vectors to supplement and/or elude human AdV (HAdV)-specific neutralizing antibodies (vector immunity). Here we evaluated the vaccine immunogenicity and efficacy of BAdV-3 vector...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Sayedahmed, Ekramy E., Hassan, Ahmed O., Kumari, Rashmi, Cao, Weiping, Gangappa, Shivaprakash, York, Ian, Sambhara, Suryaprakash, Mittal, Suresh K.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082999/
https://ncbi.nlm.nih.gov/pubmed/30101154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.07.007
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