NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. In this study, we found a novel role of NQO1 in suppressing Toll-like receptor (TLR)–mediated innate immune responses. NQO1-deficient macrophages selectively produced excessive amounts of IL-6, IL-12,...

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Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Kimura, Akihiro, Kitajima, Masayuki, Nishida, Kyoko, Serada, Satoshi, Fujimoto, Minoru, Naka, Tetsuji, Fujii-Kuriyama, Yoshiaki, Sakamato, Satoshi, Ito, Takumi, Handa, Hiroshi, Tanaka, Takashi, Yoshimura, Akihiko, Suzuki, Harumi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2018
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080903/
https://ncbi.nlm.nih.gov/pubmed/29934320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20172024
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