Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms

Interactive relationships between metabolism, inflammation, oxidative stress, and autophagy in the vascular system play a key role in the pathogenesis of diabetic cardiovascular disease. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular homeostasis, which...

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Vydáno v:Front Pharmacol
Hlavní autoři: Lazaro, Iolanda, Lopez-Sanz, Laura, Bernal, Susana, Oguiza, Ainhoa, Recio, Carlota, Melgar, Ana, Jimenez-Castilla, Luna, Egido, Jesus, Madrigal-Matute, Julio, Gomez-Guerrero, Carmen
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080546/
https://ncbi.nlm.nih.gov/pubmed/30108504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00819
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