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YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components

YC-1 [3-(5′-hydroxymethyl-2′furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to...

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Autori principali: Martin, Emil, Lee, Yu-Chen, Murad, Ferid
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC60803/
https://ncbi.nlm.nih.gov/pubmed/11687640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231486198
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