Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction

Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a major component...

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Publicado no:Sci Rep
Main Authors: Lommel, Mark, Strompen, Jennifer, Hellewell, Andrew L., Balasubramanian, Gnana Prakash, Christofidou, Elena D., Thomson, Andrew R., Boyle, Aimee L., Woolfson, Derek N., Puglisi, Kane, Hartl, Markus, Holstein, Thomas W., Adams, Josephine C., Özbek, Suat
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079037/
https://ncbi.nlm.nih.gov/pubmed/30082916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30035-2
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