Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and...

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Published in:Nat Commun
Main Authors: Ray-Gallet, Dominique, Ricketts, M. Daniel, Sato, Yukari, Gupta, Kushol, Boyarchuk, Ekaterina, Senda, Toshiya, Marmorstein, Ronen, Almouzni, Geneviève
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078998/
https://ncbi.nlm.nih.gov/pubmed/30082790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05581-y
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