The Modifying Effect of a Functional Variant at the miRNA Binding Site in E2F1 Gene on Recurrence of Oropharyngeal Cancer Patients with Definitive Radiotherapy

Human papillomavirus (HPV) activates E2F1-driven transcription via the E7-RB-E2F1 pathway. A polymorphism in the 3’ UTR of E2F1 gene may disrupt a binding site for miRNA and may affect its transcription level, thus modifying the susceptibility to radiotherapy and outcomes through this pathway. We ev...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Zhang, Hua, Sturgis, Erich, Zhu, Lijun, Lu, Zhongming, Tao, Ye, Zheng, Hongliang, Li, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2018
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078938/
https://ncbi.nlm.nih.gov/pubmed/29574328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.02.022
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