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The conundrum of depression clinical trials: one size does not fit all

In this paper we review the history of antidepressant (AD) development, since the discovery of imipramine in 1957 to the present day. Through this exploration we will show that the increasing placebo response is likely a red herring and that a higher magnitude of placebo response is not an adequate...

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Publicat a:Int Clin Psychopharmacol
Autors principals: Khan, Arif, Mar, Kaysee Fahl, Brown, Walter A.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams And Wilkins 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078483/
https://ncbi.nlm.nih.gov/pubmed/29939890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/YIC.0000000000000229
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