VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells

AIM/HYPOTHESIS: Here, our aim was to examine whether VLDL and apolipoprotein (apo) CIII induce endoplasmic reticulum (ER) stress, inflammation and insulin resistance in skeletal muscle. METHODS: Studies were conducted in mouse C2C12 myotubes, isolated skeletal muscle and skeletal muscle from transge...

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Publicat a:Diabetologia
Autors principals: Botteri, Gaia, Montori, Marta, Gumà, Anna, Pizarro, Javier, Cedó, Lídia, Escolà-Gil, Joan Carles, Li, Diana, Barroso, Emma, Palomer, Xavier, Kohan, Alison B., Vázquez-Carrera, Manuel
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078195/
https://ncbi.nlm.nih.gov/pubmed/28835988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4401-5
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