Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH(2) on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

PURPOSE: To investigate the therapeutic effects of protease-activated receptor 2 (PAR-2) agonist SLIGRL-NH(2) on loperamide-induced Sprague-Dawley (SD) rat constipation animal models. MATERIALS AND METHODS: Loperamide was injected subcutaneously to induce constipation twice a day for 3 days. SD rats...

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Detalles Bibliográficos
Publicado en:Drug Des Devel Ther
Main Authors: Zhang, Yonggang, Ge, Tingrui, Xiang, Ping, Mao, Haibing, Tang, Shumin, Li, Aimin, Lin, Lin, Wei, Yinting
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2018
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078190/
https://ncbi.nlm.nih.gov/pubmed/30122898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S160628
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