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Molecular switch-like regulation enables global subunit coordination in a viral ring ATPase

Subunits in multimeric ring-shaped motors must coordinate their activities to ensure correct and efficient performance of their mechanical tasks. Here, we study WT and arginine finger mutants of the pentameric bacteriophage φ29 DNA packaging motor. Our results reveal the molecular interactions neces...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tafoya, Sara, Liu, Shixin, Castillo, Juan P., Atz, Rockney, Morais, Marc C., Grimes, Shelley, Jardine, Paul J., Bustamante, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077733/
https://ncbi.nlm.nih.gov/pubmed/30012596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802736115
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