CAK-independent Activation of CDK6 by a Viral Cyclin

In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes a protein with similarity to D-type cyclins. This KSHV-cyclin activates CDK6, alters its substr...

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Main Authors: Kaldis, Philipp, Ojala, Päivi M., Tong, Lily, Mäkelä, Tomi P., Solomon, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC60770/
https://ncbi.nlm.nih.gov/pubmed/11739795
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