Yra1-bound RNA–DNA hybrids cause orientation-independent transcription–replication collisions and telomere instability

R loops are an important source of genome instability, largely due to their negative impact on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from yeast to humans and required for mRNA export, but its excess causes lethality and genome instability. Here, we show that,...

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Publicat a:Genes Dev
Autors principals: García-Rubio, María, Aguilera, Paula, Lafuente-Barquero, Juan, Ruiz, José F., Simon, Marie-Noelle, Geli, Vincent, Rondón, Ana G., Aguilera, Andrés
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075034/
https://ncbi.nlm.nih.gov/pubmed/29954833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311274.117
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