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Dissection, Optimization and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor
Inhibitors of the human enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH1) can control endogenous nitric oxide production. A time-dependent covalent inactivator of DDAH1, N(5)-(1-imino-2-chloroethyl)-l-ornithine (K(I) = 1.3 μM, k(inact) = 0.34 min(−1)), was conceptually dissected into two frag...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6074031/ https://ncbi.nlm.nih.gov/pubmed/29983043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00554 |
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