BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of β-amyloid (Aβ), one of the major pathogenic molecules of Alzheimer’s disease (AD), and is therefore being actively pursued as a drug target for AD. Adult hippocampal neurogenesis (AHN) is a lifelong process...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Chatila, Zena K., Kim, Eunhee, Berlé, Clara, Bylykbashi, Enjana, Rompala, Alexander, Oram, Mary K., Gupta, Drew, Kwak, Sang Su, Kim, Young Hye, Kim, Doo Yeon, Choi, Se Hoon, Tanzi, Rudolph E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073981/
https://ncbi.nlm.nih.gov/pubmed/30079376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0067-18.2018
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