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Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2

The influence of Arginine 117 of human cytochrome P450 2J2 in the recognition of ebastine and a series of terfenadone derivatives was studied by site-directed mutagenesis. R117K, R117E, and R117L mutants were produced, and the behavior of these mutants in the hydroxylation of ebastine and terfenadon...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Lafite, Pierre, André, François, Graves, Joan P., Zeldin, Darryl C., Dansette, Patrick M., Mansuy, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6073854/
https://ncbi.nlm.nih.gov/pubmed/30012976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19072066
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