Growth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice

There is no safe and efficacious vaccine against human leishmaniasis available and live attenuated vaccines have been used as a prophylactic alternative against the disease. In order to obtain an attenuated Leishmania parasite for vaccine purposes, we generated L. infantum KHARON1 (KH1) null mutants...

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Udgivet i:Sci Rep
Main Authors: Santi, Ana Maria Murta, Lanza, Juliane Sousa, Tunes, Luiza Guimarães, Fiuza, Jacqueline Araújo, Roy, Gaétan, Orfanó, Alessandra da Silva, de Carvalho, Andréa Teixeira, Frézard, Frédéric, Barros, André Luís Branco de, Murta, Silvane Maria Fonseca, do Monte-Neto, Rubens Lima
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072785/
https://ncbi.nlm.nih.gov/pubmed/30072701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30076-7
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